Effect of furacin on pyruvate metabolism.

Earlier studies have shown that Furacinl inhibits the formation of acetyl coenzyme A2 from pyruvate anaerobically (1). Acetone powder preparations of pigeon liver and rat testis were used in the early work. The results suggested that Furacin inhibits reactions mediated by pyruvic oxidase; therefore, further studies were continued with more highly purified preparations of this enzyme from pigeon breast muscle (2). Studies of the effect of Furacin on Reactions 1, 2, and 3 form the basis of this paper. The stoichiometry of these processes has been shown previously by other workers (2, 3).